Originally a San Dominican monastery, today the church is only partially intact, and there is no trace of the ancient cloister which was probably placed in front of the existing facade. Much of the building was demolished during the Fascist period following the construction of a women’s academy.
Inside the church remains a work of great value, created in 1285 by Arnolfo di Cambio: the funeral monument to Cardinal de Braye, for which they used pieces of an ancient Roman sarcophagus.
In front of the Church of San Domenico, there is a small children’s playground and a central parking. San Domenico is located in few meters from Piazza del Popolo and the Teatro Mancinelli on Corso Cavour (which can be accessed by Via Felice Cavallotti).